With so much frightening information on the COVID-19 virus, I thought it might lower the stress level to hear a little good news. This article was translated from an article on PubMed France. PubMed is a searchable database for articles published in scientific journals.
While they do not clearly state that the drugs they are testing for this virus are definitely effective and present varying points of view, if you have ever read scientific literature, most articles are very cautious about what they say and usually end with, “more testing is needed”.
My purpose in sharing this with you is to lower your stress level. Know that brilliant minds are working very hard for solutions. I have trust that solutions will be found.
Stress is very hard on the immune system. Please, take a breath, go for a walk, appreciate your loved ones, order some take out, relax, enjoy your time away from work. I am here to help. If you would like a complementary, stress reducing cranial session with your immune boosting chiropractic adjustment, please feel free to schedule an extended treatment. I have taken many steps to assure a clean, healthy and relaxing environment here.
COVID-19: Could Hydroxychloroquine Really Be the Answer?
March 18, 2020
Could the old generic malaria drug hydroxychloroquine (Plaquenil, Sanofi-Aventis, among others), which is also used for the treatment of rheumatic disease, be an essential treatment for COVID-19?
This hypothesis, put forward by some, including Professor Didier Raoult of the IHU Méditerranée Infection in Marseille, was dismissed by other eminent infectious disease specialists and dismissed as fake news recently by the Ministry of Health.
Yet it resurfaced yesterday with the presentation on YouTube by Prof Raoult of positive results in a non-randomised, unblinded trial of 24 patients.
This follows encouraging in vitro results obtained by a Chinese team led by Xueting Yao, from Peking University Third Hospital, Beijing, China, which were published online by the journal Clinical Infectious Diseases on March 9th. However, the data were deemed insufficient by the infection community to recommend the compound as a treatment.
Moreover, chloroquine is not listed among the four treatments studied as part of the recently launched European clinical trial piloted by Inserm, which includes 3200 severe hospitalised patients, including 800 French patients.
Chloroquine was ruled out due to the risk of interactions with other medications for common comorbidities in infected patients, and because of possible adverse effects in patients undergoing resuscitation.
The Marseille Study
The European Union Clinical Trials Register shows that the Marseille study was accepted on 5th March by the National Medicines Safety Agency (ANSM). It could include up to 25 COVID-19 positive patients, comprising five aged 12–17 years, 10 aged 18–64 years, and 10 more aged 65 years or over.
While the data have not yet been published, and should therefore be interpreted with caution, this non-randomised, unblinded study showed a strong reduction in viral load with hydroxychloroquine.
After 6 days, the percentage of patients testing positive for COVID-19 who received hydroxychloroquine fell to 25% versus 90% for those who did not receive the treatment (a group of untreated COVID-19 patients from Nice and Avignon).
In addition, comparing untreated patients, those receiving hydroxychloroquine and those given hydroxychloroquine plus the antibiotic azithromycin, the results showed there was “a spectacular reduction in the number of positive cases” with the combination therapy, said Prof Raoult.
At 6 days, among patients given combination therapy, the percentage of cases still carrying SRAS-CoV-2 was no more than 5%.
Azithromycin was added because it is known to be effective against complications from bacterial lung disease but also because it has been shown to be effective in the laboratory against a large number of viruses, the infectious disease specialist explained.
“Everyone who died from COVID-19 were still carriers of coronavirus. To no longer have the virus changes the prognosis,” Prof Raoult said.
More detailed results of the study have been submitted for publication in the International Journal of Antimicrobial Agents.
Study Splits Infectious Disease Community
The announcement of positive results from this small study split medical opinion.
Professor Gilles Pialoux, an infectious disease specialist at Tenon Hospital, was cautious in his response. He told Medscape’s French Edition: “The idea is interesting but we need large, randomised, controlled trials. We should not communicate this kind of information on YouTube, it is not meaningful.
“Don’t forget, this compound has not been included in Inserm’s trial because there are more interesting avenues, such as remdesivir or Kaletra [lopinavir/ritonavir]. We must be careful not to repeat the story with cyclosporin in HIV.”
Christian Perronne, head of infectious diseases, University Hospital Raymond Poincaré, Garches, Paris, was more enthusiastic.
“I really believe in hydroxychloroquine. It is a drug I find rather fascinating, that has been used for decades. There have been positive results in an in vitro study and a preliminary Chinese study in 100 patients which showed that hydroxychloroquine reduced the viral load, the symptoms lasted for less time, and they are not as severe. This could reduce the number of carriers, which I find interesting from an epidemiological perspective.
“I think from an ethical point of view, we should suggest it to all patients with severe disease who are hospitalised, under surveillance and on short treatment, paying attention to drug interactions, especially with drugs that prolong the QT interval. Afterwards, in terms of adverse effects, at increased doses, it is possible that patients will have pain or fever, but it seems that the treatment is effective at lower doses, according to the Chinese data. In any case, the adverse effects of this compound are not dangerous.”
On the adverse effects, Professor Thomas Papo, from Bichat Hospital, the University of Paris, confirmed via email: “Hydroxychloroquine (Plaquenil, which is not chloroquine), vaunted by Didier Raoult as an anti-viral, has been used for decades in tens of thousands of patients, for several decades, so we have a huge follow-up and lots of data. This drug is remarkably well tolerated and we give it to all patients with lupus (for example), including in pregnant women. The main complication (retinal toxicity) is rare and does not last beyond 5 years of continuous use.”
Hydroxychloroquine Tested in Other Hospitals
At the end of Tuesday’s Council of Ministers, Sibeth Ndiaye, a government spokesperson, discussed the results published by Prof Raoult. “The clinical trial in Marseille is a promising start; we are extending it because science requires the experience to be validated and repeated several times to be able to say whether or not it works,” she warned. Other tests will be carried out at Lille Hospital to confirm, or not, Prof Raoult’s results.
Chloroquine is currently being examined in a number of clinical studies in China and elsewhere, and some in France have also decided to suggest it following Prof Raoult’s findings.
This is the case for Dr Alexandre Bleibtreu, an internal medicine specialist at Pitié Salpêtrière Hospital, Paris, who was initially not persuaded by the in vitro data but has changed his opinion after having seen the results of the study carried out by Didier Raoult.
Contacted by CheckNews, the on-demand journalism service from Liberation, he explained that the compound was now used in almost all (approximately 50) hospitalised patients in their service, except those who refuse it or who have contraindications.
“I heard about the results, which changed my mind. We followed the Marseille protocol, and there are surely others who will use it. It is not the most obvious treatment; it works in vitro but we didn’t have data in vivo.
“The aim is not to be right but that our patients get better. No treatment is magic and the publication of the results raises questions but between doing nothing and repositioning drugs based on their adverse effects, interactions, etc, we try things as we go.”
In the UK, Robin May, Professor of Infectious Disease at the University of Birmingham, explained that there is a scientific rationale for the use of hydroxychloroquine in the treatment of COVID-19, based on its mode of action in malaria.
In a statement through the Science Media Centre, he explained that, as chloroquine is a “weak base” and so helps to neutralise acids, it makes the environment “less suitable” for the malaria parasite to live in when it diffuses into red blood cells.
While the mode of action against COVID-19 is not established, Prof May said, he pointed out that many viruses enter host cells via endocytosis, as a result of which they are initially taken up into an intracellular ‘compartment that is “typically fairly acidic”.
“Chloroquine would alter the acidity of this compartment, which can interfere with the ability of viruses to escape into the host cell and start replicating.”
He continued: “Another possibility is that chloroquine may alter the ability of the virus to bind to the outside of a host cell in the first place,” adding that the drug “has subtle effects on a wide variety of immune cells…and it may be that one of these effects helps stimulate the body’s ability to fight off COVID-19.”
Crucially, the drug is also “cheap and relatively easy to manufacture” and so could easily be put into clinical trials and, eventually, treatment, May underlined.
The study by Yao et al was supported by the “13th Five-Year” National Major New Drug Projects of China, Ministry of Science and Technology of the People’s Republic of China, and Bill & Melinda Gates Foundation.
Two of its authors have patents pending for an anti-microbial infection pharmaceutical composition and its application.
Professor Pialoux has been a board member or attended meetings for Gilead, MSD, Bristol-Myers Squibb, Janssen, Abbvie, AstraZeneca.
Clin Infect Dis. 2020 Mar 9. pii: ciaa237. doi: 10.1093/cid/ciaa237
© 2020 WebMD, LLC
Can you Heal Arthritis
As a chiropractor, a week doesn’t go by without someone asking if Arthritis can heal. Maybe they’ve been to their GP and gotten an x-ray and the report says “degenerative changes” of this joint or that joint. Or maybe they have a sore knee or back and their doctor just declares that they are old and that’s the end of the story!
I am always amazed at the responsive nature of the body. Arthritis starts with joint dysfunction. That means a joint is either not moving well or is out of alignment. This causes inflammation and additional wear and tear on the joint. Over time the smooth cartilage on the joint surfaces gets roughed up. Does it ever sound like you have sand in the joints of your neck? That’s called crepitus and it means your cartilage is getting worn.
Eventually the cartilage can get so worn that the bones come in contact with each other. Bones respond to pressure by laying down more bone. This is called Wolf’s Law. Poor Dr. Wolf, I bet he had terrible arthritis! This new bone forms spurs. If this continues the bones can fuse. While this is happening there is constant irritation and inflammation around the joint. Any nearby nerves will be irritated causing pain, muscle tension, or numbness all along the course of the nerve. Fusion is really an adaptive process because once the joint fuses, it doesn’t hurt anymore. You may have heard of back surgery where they fuse two or more vertebrae together. The problem is, that joint can no longer move. This causes more pressure on surrounding joints and the process continues.
So what is a better solution? If the problem starts with a joint not moving well or being out of alignment, the obvious solution would be to restore movement and alignment. That is the goal of all chiropractic adjusting!
Bone spurring does not go away. So that cannot be fixed. However, when function is restored to a joint, it should decrease the pain and slow the degeneration. Cartilage can rebuild as long as there is some cartilage between the joint surfaces. This is a war of attrition. The cells in the cartilage that make more cartilage have to outpace the destruction of cartilage and its fellow cells.
This is the really cool part about the body. The body is responsive. That means, when given a challenge the body will rise to that challenge even on a cellular level. If you put motion back into a joint that was not moving well and use it. Starting slowly with rehab type exercises. And you give those cells that make cartilage the nutrition they need to make more; glucosamine, chondroitin, gelatin, or collagen, you will get new cartilage growth!
Considering how good fish oil is for the brain, you would think fish would be a lot smarter. Good fish oil is comprised of Omega-3 fatty acids. These are what we call essential fatty acids because the body cannot produce enough for its own needs so we have to either eat foods containing them or supplement.
There are 4 Omega-3s that we need EPA, DHA, DPA and ALA. They have very long names. EPA has gotten a lot of attention because it is very good at reducing systemic inflammation and cardiovascular health. Most of the supplements you find on the shelf of health food stores will be either all EPA or a blend of EPA, DHA, and maybe ALA.
DPA is getting more attention in research. It is an intermediary between EPA and DHA which means the body can convert it into either one. It has some of the benefits of both EPA and DHA for cardiovascular health, reducing inflammation, may be related to depression and schizophrenia and oxidative damage to the brain. Taking DPA with EPA and DHA actually increases the absorption of EPA and DHA and helps balance the Omega-6 to Omega-3 ratio. Currently DPA is available as a supplement and is found in some Omega-3 blends, but I think we will be seeing more and more of it as research continues.
The brain is about 60% fat. DHA makes up about 40% of that as one of the main ingredients of the cell walls or membranes. It is about 97% of the Omega-3 fatty acids in the brain. When we consider diseases or degeneration of the brain such as Alzheimer’s disease, autism, MS, dementia or even mild cognitive decline and memory loss, they are all a function of nerves not communicating with each other properly. This failed communication most often has brain inflammation at its root cause. DHA is anti-inflammatory within the brain so it is neuroprotective. Supplementing with DHA has been shown to lessen all of the above issues.
If you are deficient in DHA and the brain needs it to control inflammation, the brain will start pulling it from the cell walls of neurons. This makes those neurons less responsive and resilient and can even kill them, which leads to more inflammation.
Increasing DHA levels in the brain have many benefits. For example, with concussion aka mild traumatic brain injury, a very sudden cause of brain inflammation, studies have shown that supplementing before a mTBI with DHA or right after mTBI lessens the damage to neurons and neuron death. It helps restore levels of chemicals that help neurons connect, so head injured rats recovered their able to learn and remember better than those without DHA. It lessens microglial activation, a type of brain cell that when activated makes the brain more susceptible to becoming inflamed. Even 30 days after injury DHA helps restore energy production in the neurons lessening ongoing damage. If you think of cognitive decline, Alzheimer’s and other neurodegenerative diseases as traumatic brain injury over a long period of time, you can see how using DHA preventatively would be very beneficial.
How much Fish
So you may be asking yourself, “Why don’t you tell me how much of each Omega-3 I should be taking?” And the answer is, “Because I do not know.” And here is why I don’t know.
There really is no established dosage. Most of the titles of studies on head injury and fatty acids end in the words, “in rats”. Recommendations for general health usually recommend a 1:1 or 2:1 EPA to DHA ratio and range anywhere from 500 to 5000mg total Omega-3s per day. EPA is more important for general inflammation, but if you care more about brain health, the focus should be on DHA. For general maintenance and well-being I like to recommend a formula that has 650mg of EPA and 450mg of DHA. In cases where there is brain inflammation, I like to add 1200mg or more of a liquid form of DHA.
Of course, a lot depends on quality. When you purchase your Omega-3 fatty acids, do make sure that you get them from a reputable company. Studies have shown that some Fish Oil supplements have other fats in them or oxidized, aka rotten fats. One of the main functions of the fish oil is as an anti-oxidant. You can see how they wouldn’t work well if already oxydized.
you take a high dose of Fish Oils and get crampy or have a lot of fish tasting
burps, it could mean that the oil is spoiled or your digestive system is not
able to digest fat well. This could mean an issue with your pancreas or gall
bladder or the connection between your brain and digestive system the Vagus
nerve. Keeping your fish oils in the fridge may help and always take them with
food. You may need a new bottle or different brand of oils or a liquid form. If
work, reduce what you are taking. Still having trouble? Try gargling and
singing, it stimulates the Vagus nerve. I guess fish are gargling pretty much
all the time. Maybe they are smarter than we think after all.
Aiguo Wu, Zhe Ying, and Fernando Gomez-Pinilla Dietary Omega-3 Fatty Acids Normalize BDNF Levels, Reduce Oxidative Damage, and Counteract Learning Disability after Traumatic Brain Injury in Rats, Journal of Neurotrauma 2004 21:10, 1457-1467.
James D. Mills, Kevin Hadley, Julian E. Bailes, Dietary Supplementation With the Omega-3 Fatty Acid Docosahexaenoic Acid in Traumatic Brain Injury, Neurosurgery, Volume 68, Issue 2, February 2011, Pages 474–481, https://doi.org/10.1227/NEU.0b013e3181ff692b
Aiguo Wu, Zhe Ying, and Fernando Gomez-Pinilla The Salutary Effects of DHA Dietary Supplementation on Cognition, Neuroplasticity, and Membrane Homeostasis after Brain Trauma, Journal of Neurotrauma 2011 28:10, 2113-2122.
Lloyd D. Harvey, Yan Yin, Insiya Y. Attarwala Administration of DHA Reduces Endoplasmic Reticulum Stress-Associated Inflammation and Alters Microglial or Macrophage Activation in Traumatic Brain Injury. https://doi.org/10.1177/1759091415618969
R. Preston Mason,Samuel C.R. Sherratt Omega-3 fatty acid fish oil dietary supplements contain saturated fats and oxidized lipids that may interfere with their intended biological benefits. Biochemical and Biophysical Research Communications, Elsevier, 29 January 2017.
What if there was one word, one concept that embodied the most significant quality of health and well-being? What do you think that word would be. Well you know I’m a chiropractor, so you might guess that I would say something related to the nervous system, or maybe the alignment of the spine. Maybe preventing Tech Neck. You would warm, but in my mind the single most important thing for health is…
Can Coffee Make You Tired?
Caffeine is the most common psychotropic drug in use. It’s legal and it is oh so good. We drink coffee to battle fatigue, a quick energy boost, and oddly, to relax. But does it really do what we think it does? There is information coming out praising coffee and caffeine in general as being helpful against Alzheimer’s, diabetes and heart disease, but does that really mean that it’s healthy?
The Power of a Healthy Nervous System
Why is it important to make time for your Nerves? You may come home from work every day completely exhausted.You may spend most of your day taking care of your family with precious little time for yourself. Or you could be a single parent who does it all: makes breakfast, lunch and dinner for everyone, works at a high-pressure job, and rarely has a spare minute to savor anything. Or perhaps you’re an über-busy executive, laser-focused on your business from early morning to late at night, five to seven days a week.
No matter what your situation, if you don’t make time for yourself to see your chiropractor, you’re not being proactive in maintaining good back and neck health. Your nervous system is suffering and you are missing out on having a higher level of energy and vitality.
Jaw Problems and Headaches Are Often Interrelated
Do you ever wonder if jaw problems aka tmj cause headaches? Do you ever wake up in the morning, yawn or chew, and hear your jaw click? Do you think your jaw issues and your headaches could be connected to each other?
Concussion can be sneaky. It happens when your brain hits the inside of your skull. You don’t even need to hit your head. Whiplash injuries, that are common in car accidents and sports, jar the head forcefully and can cause just as much damage as being struck.
Advice from a Chiropractor
Do you have a series of head pain that just won’t go away and are affecting you at work or while playing sports? Does the pain of migraines stop you in your tracks? Do your sinuses ache? Is stress bothering you? Do you have intermittent dizzy spells?
Don’t you wish there was a way to have someone prevent you from having to yell, “Why does my head hurt?’
In this article, I discuss the types of headaches that my patients have –– and how I resolve their problems with chiropractic care.
Clayton Kershaw. Andrew Bogut. Tony Romo. Tiger Woods. Peyton Manning. What do all of these different athletes have in common? A herniated disc.
They’ve all been in the news over the last few years because of disc herniations in their backs, which can be very painful, even excruciating.
In fact, Clayton Kershaw, the L.A. Dodgers’ pitching ace, was first diagnosed with a disc herniation in his back in June, and was just moved to a 60-day disabled list, meaning he can’t throw, catch or even pick up a baseball until at least late August.
In my most recent article, “Does a Chiropractor Need to Crack My Back?”, I discussed the pros and cons of twisting the body to crack your back. It’s not always the best way to relieve pain and pressure on the facet joints connecting each of your 33 vertebrae.
In this article, I’ll move up your spine a bit and discuss the practice of cracking your neck.
Concussions are an everyday occurrence in a wide range of sports. Many of my patients are sports enthusiasts and it is not uncommon to hear that they have had one or multiple concussions over their lifetimes.
You might have heard about or seen the movie Concussion, where accomplished pathologist, Dr. Bennett Omalu, uncovers the truth about brain damage among Pittsburgh Steelers and other football players who had suffered from repeated head trauma. The truth is, a concussion head injury isn’t limited to professional athletes.
Stretches You Can Do at Your Desk
Going from the bed to the car to the desk to the sofa, many of my patients feel the need to stretch, but just don’t take the time. When you are sitting all day, you need to stretch to avoid the aches and pains that come with a stiff body. You may not have an hour a day to do a stretch or yoga class, but, it’s important to stretch a little bit frequently to really stay flexible. A good stretch begins from a position of good posture. When stretching at your desk, make sure you have your ergonomics set up first to minimize stress on the body. When you are sitting properly, it will be easier to stretch at your desk or even in your car.
“Oh, my aching back!” Why does your back hurt today and not yesterday? Did you pick something up that was too heavy without bending your legs? Did you sleep with your neck off the side of the pillow? Or did you just wake up and your back suddenly hurt? If you were to ask these questions to my patients, you would hear all sorts of answers. It’s amazing how many myths about back pain there are. To help you understand exactly why your back might be hurting, here are the 5 most common myths that I discuss with my patients and the answers you need to know.
San Rafael Chiropractor Shares Advice
According to the Arthritis Foundation, an estimated 50 to 80% of American adults will experience back pain. When your back hurts, you want to know the cause so you can do something about it.
But, reasons vary and they are often hard to figure out. We all have 24 vertebrae that can get knocked out of line, strained, twisted, or compressed and that can happen in many different ways leading to pain.
5 Proven Techniques from a Chiropractor
Many people realize that their neck or back pain becomes worse after sitting for extended or sometimes even short period of times. In our culture, most of us spend much of our day seated, whether it’s on the drive to work, at a desk in front of a computer , eating and even relaxing on the sofa after a long day. No matter where you are sitting, the same posture and ergonomic concerns apply. The more you are able to apply the following guidelines, the less stress you will have on your spine and the less likely you will be to experience back or neck pain.
You probably haven’t actively thought about how to strengthen your neck, but you wake up after you “slept funny” and you’ve got a crick. Then that crick turns into a lot of pain in and around your neck that just won’t go away by itself. At this point most people start to wonder if a Chiropractor would be good solution or if this is “just” neck pain they will have to live with. The good news, a chiropractor can help you with neck issues.
Do you have headaches more than a few times a week? Are they tension headaches? Or are they migraines? At Balance Chiropractic, many of my patients seek headache help in San Rafael, because their pain can be caused by a wide variety of problems.
In this article I’ll be discussing how you can be treated with chiropractic techniques and cranial therapies to ease your headache pain. I offer a variety of therapies to analyze and correct most issues that address the needs of headache suffers.
What is Causing My Constant Headache?
If you’ve found this page, there’s a good chance that you’re one of the millions of people who suffer from headache. In fact, you may already know that a severe headache is the #1 reason for missing work. So, if you’re one of those folks who’s tired of missing work or loosing quality time with friends and family, because your head throbs or bright lights hurt your eyes, this article is for you.
Chiropractic Solutions for Athletes
When you think about it, Marin is like a giant park, with all kinds of wonderful and easily accessible indoor and outdoor activities to keep you fit, trim and in great shape. It’s our own slice of paradise.
Whether you’re a weekend warrior, training for a triathlon, the Dipsea Race or the Double Dipsea (for you masochists out there), it’s fairly common to tweak a muscle or joint.
How Chiropractic Helps Backs Feel Better
“Oh my aching back,” is a phase I’ve heard all too often in my chiropractic office and it’s not surprising as back pain is one of the most common issues I treat. The fact that you found this article tells me that you most likely have some kind of back pain.
In this article, I’ll outline some of the common causes for lower and upper back ailments, then I’ll describe how I treat them.